Mesothelioma

"We are getting closer and closer to making an impact on this insidious disease," said Anil Wali, Ph.D., an associate professor with Karmanos who led a group of cross-collaborative researchers in studying the ubiquitin-proteasome proteolytic (UPP) pathway regulatory proteins.

Their study demonstrated that protein ubiquitination and degradation are critical players in the spread of After studying 241 genes involved in the UPP pathway, Wali's group determined 33 genes were differentially expressed among epithelioid and biphasic histotypes.

"We have already reported earlier detection biomarkers that can be utilized in assessing the high risk groups of patients," Dr.

Wali said.

"Now, if we can develop a therapy to target this pathway, we will be one step closer to halting this disease." Malignant pleural Despite advances in cancer treatment, the average survival rate remains low and the majority of patients die within two years of diagnosis.

Currently there is no cure.

The Karmanos Cancer Institute has a long history of In 2004, the Institute joined with Wayne State University's Center for Occupational and Environmental Medicine to create the National C...

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