Mesothelioma

... PharmaLive: Alzheimer's Drug Shows Promise in Fighting Cancer TRIAL RESULTS Alzheimer's Drug Shows Promise in Fighting Cancer LOS ANGELES, April 17, 2007 /PRNewswire/ - Researchers from the Barbara Ann Karmanos Cancer Institute in Detroit, MI presented strong evidence today that an antibiotic typically prescribed for Alzheimer's patients could be effective in eventually treating certain types of cancers.

Q.

Ping Dou, Ph.D., leader, Prevention Program at Karmanos, and members of his lab announced the findings of their study showing that the drug Clioquinol (CQ) appears to have an anti-tumor effect in mice bearing human prostate cancer cells.

The announcement was made at the American Association of Cancer Research (AACR) annual meeting in Los Angeles, CA.

Dr.

Dou and his team turned to the copper-binding compound CQ after discovering that prostate, breast, brain, colon and lung tumor tissue often have a higher level of copper than normal tissue.

According to Dr.

Dou, this led his team to investigate whether cancers with high levels of copper can lead to targeted treatment.

Karmanos researchers found that after binding CQ to the copper in prostate tumor tissue, the drug induces cell death in human prostate cancer cells.

According to Dr.

Dou, his lab will take this information and work with Karmanos clinicians to create a treatment selectively targeting the copper found in tumors.

"We want to find out if we can target cancers that express high levels of copper," says Dr.

Dou....

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