Mesothelioma

So, we start with CA125.

And then, we add additional markers to that.So, we started with some that we had identified ourselves.

And, we put mesothelium was the first one.

And, HE4 was the second that we identified ourselves.

But, we felt that there was- it was unlikely that the markers that we had come up with would be sufficient.

So, we invited collaborators from all around the country who had markers to test their markers on our blood samples.So, we sent them blinded blood samples.

And, they measured their markers.

And then, we tried to put together a panel.

So, the first one that we looked at was mesothelium because it was the first one that we had.And, it did appear to compliment CA125.

And, by that I mean that some of the cancers that CA125 was missing were i- were picked up by mesothelium so that if you used a decision rule that said if either CA125 or mesothelium is elevated, then we'll call this test positive.

Then- mesothelium added something to CA125 in a panel.

And, that's kind of the criteria that we use in identifying all of these- markers to see if they contribute to the panel.The problem with what we've been doing is that we had been doing that with samples that were obtained at the time of diagnos...

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